• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention discloses a process for manufacturing tablets using a press provided with at least one compression chamber having an upper and a bottom mold and a lubrication device having at least one two-substance nozzle which sprays the lubricant onto the walls of said compression chamber in a cone shaped pattern, wherein at least one additive is added to the lubricant to thereby apply the additive onto the surface of the tablets during the manufacturing process.
    公开号:US20010001512A1
    申请号:US09/761,032
    申请日:2001-01-16
    公开日:2001-05-24
    发明作者:Gunter Voss
    申请人:Gunter Voss；
    IPC主号:B29C43-20
    专利说明:
    [0001] The present application is a continuation-in-part of copending U.S. patent application Ser. No. 08/675,775, filed Jul. 3, 1996. [0001] FIELD OF THE INVENTION
    [0002] The prevent invention relates to a process for manufacturing tablets using a press provided with at least one compression chamber having an upper and a bottom mold and a lubricating device having at least one two-substance nozzle, wherein the nozzle sprays the lubricant so that it is deposited on the walls of the compression chamber in a cone shaped pattern. [0002] BACKGROUND OF THE INVENTION
    [0003] Processes for manufacturing tablets are often executed on tablet presses such as round presses. Round presses are provided with a number of processing stations in which the individual processing steps required for manufacturing tablets are executed. In other words, when an additive is to be added to the manufacturing process of a tablet, the setup of the press has to be changed accordingly. However, it is frequently impossible to add another processing station to the existing setup, because the dimensions of the press are determined by the setup of the round table. Therefore, when additives, such as flavoring or coloring substances for instance, are to be applied to the tablet as a coating, a separate step is required, which is usually executed in a device separate from the tablet press. [0003]
    [0004] Processes for manufacturing tablets as such can be executed by using the apparatus disclosed in German Patent No. DE 41 03 413 C1. According to DE 41 03 413 C1, the lubricant is applied to the compression tool of a tablet press by a two-substance nozzle provided with an inner nozzle, coaxially surrounded by an annular space. [0004] SUMMARY OF THE INVENTION
    [0005] An object of the prevent invention is to provide a process for manufacturing tablets in which at least one additive can be added to the manufacturing process at any time without altering the setup of the press. [0005]
    [0006] This and other objects of the present invention are achieved by provision of a process for manufacturing tablets using a press provided with at least one compression chamber having an upper and a bottom mold and a lubricating device having at least one two-substance nozzle which sprays the lubricant onto the walls of the compression chamber in a cone shaped pattern, wherein at least one additive is added to the lubricant to thereby apply the additive onto the surface of the tablets during the manufacturing process. Thereby, a tablet is obtained comprising an inner region of compressed tablet substance having a volume in the range of 85% to 95% of the total tablet volume and an outer surface region of compressed additive having a volume in the range of 5% to 15% of the total tablet volume. [0006]
    [0007] Other objects, advantages and novel features of the present invention will become apparent from the following detailed description of the invention when considered in conjunction with the accompanying drawings. [0007] BRIEF DESCRIPTION OF THE DRAWINGS
    [0008] FIG. 1 is a schematic representation of an apparatus for executing the process according to the present invention; [0008]
    [0009] FIG. 2 represents a longitudinal cross section of a two-substance nozzle according to DE 41 03 413 C1; [0009]
    [0010] FIG. 3 represents a cross sectional view of the two-substance nozzle taken along I-I of FIG. 2; and, [0010]
    [0011] FIG. 4 represents a detailed view of the front face of a two-substance nozzle. [0011] DETAILED DESCRIPTION OF THE INVENTION
    [0012] An element of the prevent invention is that at least one additive is added to the lubricant that is applied to the walls of the press. The present process permits the introduction of additives onto tablets at precise dosages during the manufacturing process without interfering with the setup of the press. [0012]
    [0013] The process of the present invention can be executed by using the apparatus shown in FIG. 1. [0013]
    [0014] FIGS. 2 and 3 represent a two-substance nozzle as disclosed in DE 41 03 413 C1, wherein the two-substance nozzle has a cylindrical shaped body [0014] 3 with two gas inlets 51, 52, a gas outlet 33, a shell 31 and a front face 32. The body 3 of the two-substance nozzle is also provided with an inner nozzle 2, surrounded by an annular space 4.
    [0015] FIG. 4 represents an detailed view of the front face of a two-substance nozzle, showing the inner nozzle and the sharp edge break of the nozzle. [0015]
    [0016] According to the process of the present invention, the proportion of lubricant to additive is in the range of 5 to 95% and 95 to 5%. [0016]
    [0017] In a preferred embodiment, these additives are flavoring or coloring substances, wherein the flavoring substances may be common commercial sweeteners. In this case, the substance or substances may be mixed with a carrier and then added to the lubricant. [0017]
    [0018] In another preferred embodiment, the additive might be one or more bittering agents in a water-soluble preparation. The application of such bittering agents to tablets is useful to prevent inadvertent misuse by children. In this case, it might is be necessary to include instructions for washing the tablets prior to intake in order to remove the bittering agent. [0018]
    [0019] In another preferred embodiment, the additive is applied as a coat of film onto the surface of the tablet, wherein the additive is first mixed with a film former and then added to the lubricant to form a mixture. The mixture is then applied with a device, such as that disclosed in DE 41 03 413 C1, onto the surface or onto selected surface areas of the compression chamber and of the active tool of the compression chamber to thereby coat the tablet with the additive during the manufacturing process. [0019]
    [0020] According to the process of the present invention, it is particularly advantageous to apply the additives in a melted state onto the walls of the compression chamber by using at least one heatable two-substance nozzle. [0020]
    [0021] In a further preferred embodiment, a nozzle having a proportional piezoelectronic valve, preferably in the feed means, is used, which permits precise work even at high temperatures and pressures. In this regard, it is noted that U.S. Pat. No. 4,388,343 discloses a method and an apparatus comprising, for instance, piezoelectronic transducers. [0021]
    [0022] A valve of this type is proportionally triggered and ensures exact dosages of the additive by adjusting the flow amount and the cross section. The triggering of such a valve is preferably controlled by a computer or an electronic control unit, which receives signals from pressure and/or temperature sensors for example. [0022]
    [0023] According to the present invention, the additive may be a sweetener such as Aspartam and Eudragit RL 30 D or a colorant such as Sikovit green lacquer. [0023]
    [0024] The present invention, therefore, provides a process for manufacturing tablets in which at least one additive can be added to the manufacturing process at any time without altering the setup of the press. [0024]
    [0025] Although the invention has been described and illustrated in detail, it is to be clearly understood that the same is by way of illustration and example, and is not to be taken by way of limitation. The spirit and scope of the present invention are to be limited only by the terms of the appended claims. [0025]
    权利要求:
    Claims (13)
    [1" id="US-20010001512-A1-CLM-00001] 1. A process for manufacturing tablets, comprising the steps of:
    mixing an additive and a lubricant to obtain a mixture, said additive comprising at least one of a flavoring substance, a coloring substance, a sweetener, and a bittering agent;
    spraying the mixture onto inner surfaces of a compression chamber;
    filling a tablet substance into the compression chamber; and
    compressing the tablet substance and the mixture simultaneously to obtain a tablet comprising an inner region of compressed tablet substance having a volume in the range of 85% to 95% of the total volume of the tablet and an outer surface region of compressed additive having a volume in the range of 5% to 15% of the total volume of the tablet.
    [2" id="US-20010001512-A1-CLM-00002] 2. The process according to
    claim 1 , further comprising the steps of mixing a flavoring or coloring substance with a carrier and then adding the flavoring or coloring substance and the carrier to the lubricant.
    [3" id="US-20010001512-A1-CLM-00003] 3. The process according to
    claim 1 , comprising the step of applying the additive as a coat of film onto the surface of the tablet, wherein the additive is first mixed with a film former and then the additive and film former are added to the lubricant.
    [4" id="US-20010001512-A1-CLM-00004] 4. The process according to
    claim 1 , comprising the steps of melting the additive with at least one heatable two-substance nozzle to form a melted additive and then applying the melted additive onto the walls of the compression chamber.
    [5" id="US-20010001512-A1-CLM-00005] 5. The process according to
    claim 1 , comprising the steps of adding the additive to the lubricant with a proportional valve to thereby control the dosage of the additive.
    [6" id="US-20010001512-A1-CLM-00006] 6. The process according to
    claim 1 , wherein the proportion of lubricant to additive is in the range of 5 to 95% and 95 to 5%.
    [7" id="US-20010001512-A1-CLM-00007] 7. The process according to
    claim 1 , wherein said additive comprises said flavoring substance.
    [8" id="US-20010001512-A1-CLM-00008] 8. The process according to
    claim 1 , wherein said additive comprises said coloring substance.
    [9" id="US-20010001512-A1-CLM-00009] 9. The process according to
    claim 1 , wherein said additive comprises said bittering agent.
    [10" id="US-20010001512-A1-CLM-00010] 10. The process according to
    claim 1 , wherein said additive consists of said flavoring substance.
    [11" id="US-20010001512-A1-CLM-00011] 11. The process according to
    claim 1 , wherein said additive consists of said coloring substance.
    [12" id="US-20010001512-A1-CLM-00012] 12. The process according to
    claim 1 , wherein said additive consists of said bittering agent.
    [13" id="US-20010001512-A1-CLM-00013] 13. The process according to
    claim 1 , wherein said additive comprises said sweetener.
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    JPS63243234A|1988-10-11|Molding method for member of ti-al intermetallic compound
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    同族专利:
    公开号 | 公开日
    US6620358B2|2003-09-16|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    JP2013052408A|2011-09-02|2013-03-21|Shinkusu:Kk|Metal tube bending apparatus, and method for pressurizing water-soluble lubricant|
    US20150217489A1|2014-02-04|2015-08-06|Kikusui Seisakusho Ltd.|Compression Molding Machine and Method of Producing Molded Product|
    US10334867B2|2014-03-03|2019-07-02|Intercontinental Great Brands Llc|Method for manufacturing a comestible|
    US10973238B2|2011-03-11|2021-04-13|Intercontinental Great Brands Llc|System and method of forming multilayer confectionery|
    US11122815B2|2011-07-21|2021-09-21|Intercontinental Great Brands Llc|System and method for forming and cooling chewing gum|US3096248A|1959-04-06|1963-07-02|Rexall Drug & Chemical Company|Method of making an encapsulated tablet|
    US3577490A|1967-10-02|1971-05-04|Miles Lab|Effervescent tablet and process for making same|
    CH628572A5|1977-04-20|1982-03-15|Thomae Gmbh Dr K|METHOD FOR SPRAYING THE COMPRESSION TOOLS OF MACHINES FOR PRODUCING MOLDINGS.|
    ES485764A1|1978-11-15|1980-10-01|Thomae Gmbh Dr K|Method and apparatus for dotting moulding devices by means of discrete droplets of a liquid or suspended lubricant during the manufacture of moulded objects in the pharmaceutical, food or catalytic field.|
    DE3312634A1|1983-04-08|1984-10-11|Dr. Karl Thomae Gmbh, 7950 Biberach|IMPROVED METHOD AND DEVICES FOR POINTING MOLDING TOOLS WITH DROPLETS OF LIQUID OR SUSPENDED LUBRICANTS IN THE PRODUCTION OF FORMS IN THE PHARMACEUTICAL, FOOD OR CATALYST AREA|
    GB8530365D0|1985-12-10|1986-01-22|Univ Bath|Manufacture of moulded products|
    US5356577A|1988-04-02|1994-10-18|Dr. Karl Thomae Gmbh|Controlled release of metered quantities of finely divided solids with a venturi nozzle and regulated control|
    DE4203273A1|1991-02-05|1992-08-27|Voss Gunter M|Coating surface with substance dispersed in evaporable liq. - with nozzle providing intermittent supply of liq. and continuous supply of gas, for lubrication of medical tablet prodn. equipment|
    DE4103413C1|1991-02-05|1992-11-12|Gunter M. 8918 Diessen De Voss||US20040052843A1|2001-12-24|2004-03-18|Lerner E. Itzhak|Controlled release dosage forms|
    NZ552514A|2001-12-24|2008-08-29|Teva Pharma|Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it|
    CA2714190C|2008-02-28|2018-01-16|Nishanth Gopinathan|Tablets and preparation thereof|
    法律状态:
    2007-03-06| FPAY| Fee payment|Year of fee payment: 4 |
    2011-03-09| FPAY| Fee payment|Year of fee payment: 8 |
    2015-04-24| REMI| Maintenance fee reminder mailed|
    2015-09-16| LAPS| Lapse for failure to pay maintenance fees|
    2015-10-12| STCH| Information on status: patent discontinuation|Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
    2015-11-03| FP| Lapsed due to failure to pay maintenance fee|Effective date: 20150916 |
    优先权:
    申请号 | 申请日 | 专利标题
    US67577596A| true| 1996-07-03|1996-07-03||
    US09/761,032|US6620358B2|1996-07-03|2001-01-16|Process for manufacturing tablets|US09/761,032| US6620358B2|1996-07-03|2001-01-16|Process for manufacturing tablets|
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